Thrombocytopenia associated with Acute Hepatitis B

Though hepatitis B virus (HBV) mainly affects hepa- tocytes, HBV has been shown to cause extrahepatic manifestations including serum sickness-like syndrome, glomerulonephritis, polyarteritis nodosa, dermatologic condition and hematological manifestations (1,2). These hematological manifestations include lymphocytosis, anemia, pancytopenia, pure red cell aplasia and agranu- locytosis. Isolated thrombocytopenia associated with acute HBV infection is very rare (2,3,4,5). Here we report a case with thrombocytopenia during the course of acute HBV infection. To our knowledge, this is the fifth case in the literature reporting isolated thrombocytopenia associated with acute HBV infection.